Paracetamol !
•Brand names - Crocin, Dolo, Calpol, Parasafe, Tylenol, Panadol, Paraglass •Class - NSAID •Uses - Analgesic & Antipyretic (reduces pain and fever) •Commonly used doses - 325mg, 500mg, 650mg, 1 gram •Frequency - every 6th hourly •Toxic dose - not to exceed 4 grams/ day Dose modifications done in - • Children • Individuals with severe renal impairment • Individuals with hepatic impairment / active liver disease (Since it is metabolized in liver, the risk of toxicity is more in individuals with impaired hepatic function. If it cannot be avoided in individuals with hepatic impairment, limit the therapy to short term use with dose not exceeding 2 grams/ day) • Pregnancy and lactation - lowest possible dose for shortest possible duration Mechanism of Action - •PCM has a central analgesic effect ( mediated through activation of descending serotonergic pathways) and raises pain threshold, thereby reducing pain. •But it...